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General information

Name (center, department, group or other)
Lipid group, Dept Drug Design and Pharmacology, University of Copenhagen
Contact name
Harald S. Hansen
Contact title
Professor
Date
26. June 2015


Brief description of research activities

Focus is on two research areas:
1) sensing of dietary fat in the gut and signalling to the brain appetie center for regulation of food intake
2) imaging of brain lipids in relation to ischaemia, both structural lipids and signalling lipids, as well as lipids which can function as markers of specific cell types.

Research tools and techniques

Imaging mass sepctrometry (DESI and MALDI)
mouse models of behaviour in relation to volunteric intake of dietary fat
dopamine response in relation to intake of dietary fat

Scientific Personnel

No of Associate Professors/Postdocs: 2
No of PhD students: 2
Other: 1

Key references from within the last 5 years

Pertwee R, Howlett AC, Abood ME, Alexander SPH, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, Ross RA (2010) International Union of Pharmacology Cannabinoid receptors and their ligands: Beyond CB1 and CB2. Pharmacol Rev, 62; 588-631.
Wellner N, Tsuboi T, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch D, Ueda N, and Hansen HS, (2011) Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. Biochim Biophys Acta Mol Cell Biol Lipids, 1811, 508-512.
Janfelt C, Wellner C, Leger PL, Kokesch-Himmelreich J, Hansen SH, Charriaut-Marlangue C, Hansen HS (2012) Visualization by mass spectrometry of two-dimensional changes in rat brain lipids, including N-acylphosphatidylethanolamines, during brain ischemia. FASEB J 26; 2667-2673.
Hansen HS (2014) Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat. Pharmacol Res, 86; 18-25.
Kleberg Jacobsen AK, Ferreira JG, Windeløv JA, Rehfeld JF, Holst JJ, de Araujo IE, Hansen HS. (2015) Sensing of triacylglycerol in the gut: Different mechanisms for fatty acids and 2-monoacylglcerol. J. Physiol. 593; 2097-2109.


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Denmark
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info@thebrainprize.org
www.thebrainprize.org
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