Neuroscience in Denmark


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General information

Name (center, department, group or other)
Laboratory of Neuropsychiatry
Contact name
Gitta Wörtwein
Contact email
gitta#dot#woertwein#at#regionh#dot#dk
Contact title
Lektor
Date
26. June 2015
(Last edited: 1. March 2018)

Brief description of research activities

The Laboratory of Neuropsychiatry is the research laboratory of Psychiatric Center Copenhagen, and is also part of the University of Copenhagen. The laboratory was founded in 1898 and has been located at the psychiatric department at Rigshospitalet (Copenhagen University Hospital) since 1934. The laboratory is headed by a steering group consisting of Anders Fink-Jensen, Gitta Wörtwein, and Morgane Thomsen.
Main research areas
We investigate the biological mechanisms underlying psychiatric disorders and circadian rhythms. Principal lines of investigation in the laboratory focus on drug and alcohol addiction, specifically the Glucagon-like peptide-1 system and the muscarinic system; psychosis with special emphasis on the interaction between the muscarinic and the dopaminergic transmitter system, and circadian rhythms with special emphasis on central nervous system clock genes.


Keywords

muscarinic receptors, drug addiction, depression, schizophrenia, animal models, stress, glucagon-like peptide 1 receptor, neuroplasticity, oxidative stress

Research tools and techniques

behavioral assesment of rodents, microdialysis, immunohistochemistry, insituhybridization, stereology

Scientific Personnel

No of Associate Professors/Postdocs: 3
No of PhD students: 2
Other: 5

Key references from within the last 5 years

Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats. Dencker, D., Molander, A., Thomsen, M., Schlumberger, C., Wortwein, G., Weikop, P., Benveniste, H., Volkow, N. D. & Fink-Jensen, A. 21 nov. 2017 I : Alcoholism: Clinical and Experimental Research.

Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine. Dall, C., Weikop, P., Dencker, D., Molander, A. C., Wörtwein, G., Conn, P. J., Fink-Jensen, A. & Thomsen, M. 1 jul. 2017 I : Drug and alcohol dependence. 176, s. 154-161 8 s.

Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats. Aalling N, Hageman I, Miskowiak K, Orlowski D, Wegener G, Wortwein G. J Neurosci Res. 2018 Jan;96(1):103-116

The Circadian Oscillator of the Cerebral Cortex: Molecular, Biochemical and Behavioral Effects of Deleting the Arntl Clock Gene in Cortical Neurons. Bering, T., Carstensen, M. B., Wörtwein, G., Weikop, P. & Rath, M. F. 3 jan. 2017 I : Cerebral Cortex.

Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. Reddy, I. A., Pino, J. A., Weikop, P., Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wortwein, G., Reyes, J. G., Graham, D., Stanwood, G. D., Hackett, T. A., Patel, S., Fink-Jensen, A., Torres, G. E. & Galli, A. 17 maj 2016 I : Translational psychiatry. 6, s. e809

The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice. Sørensen, G., Reddy, I. A., Weikop, P., Graham, D. L., Stanwood, G. D., Wortwein, G., Galli, A. & Fink-Jensen, A. 1 okt. 2015 I : Physiology & Behavior. 149, s. 262-8 7 s.

Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice. de la Cour C, Sørensen G, Wortwein G, Weikop P, Dencker D, Fink-Jensen A, Molander A. Eur J Pharmacol. 2015 Jan 5;746:1-5.

Electroconvulsive stimulation, but not chronic restraint stress, causes structural alterations in adult rat hippocampus--a stereological study. Olesen MV, Wörtwein G, Pakkenberg B. Hippocampus. 2015 Jan;25(1):72-80.
Addiction-related effects of DOV 216,303 and cocaine: A comparative study in the mouse. Sørensen G, Husum H, Brennum LT, Bundgaard C, Montezinho LC, Mørk A, Wörtwein G, Woldbye DP. Basic Clin Pharmacol Toxicol. 2014 Jun;114(6):451-9.

Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, Sørensen G, Andresen B, Madsen KL, Jørgensen TN, Wörtwein G, Woldbye DP, Sitte H, Daws LC, Gether U. J Biol Chem. 2013 Sep 20;288(38):27534-44.

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G, Gether U. Nat Commun. 2013;4:1580.

Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
thebrainprize@lundbeckfonden.com
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund