Neuroscience in Denmark


Back to overview


General information

Name (center, department, group or other)
Laboratory of Neuropsychiatry
Contact name
Gitta W÷rtwein
Contact email
gitta#dot#woertwein#at#regionh#dot#dk
Contact title
Lektor
Date
26. June 2015
(Last edited: 1. March 2017)

Brief description of research activities

The Laboratory of Neuropsychiatry investigates the biological mechanism underlying psychiatric disorders and circadian rhythms. Research in the laboratory focuses on drug and alcohol abuse, psychosis (with special emphasis on the interaction between the muscarinic and the dopaminergic transmitter systems), affective disorders (including seasonal affective disorder), the effects of stress and electroconvulsive therapy on the brain, and circadian rhythms (with special emphasis on CNS clock genes, the circadian expression of these genes, and the regulation and generation of these rhythms).



Keywords

muscarinic receptors, drug addiction, depression, schizophrenia, animal models, stress, glucagon-like peptide 1 receptor, neuroplasticity, oxidative stress

Research tools and techniques

behavioral assesment of rodents, microdialysis, immunohistochemistry, insituhybridization, stereology

Scientific Personnel

No of Associate Professors/Postdocs: 3
No of PhD students: 2
Other: 5

Key references from within the last 5 years

1: Bering T, Carstensen MB, W÷rtwein G, Weikop P, Rath MF. The Circadian
Oscillator of the Cerebral Cortex: Molecular, Biochemical and Behavioral Effects
of Deleting the Arntl Clock Gene in Cortical Neurons. Cereb Cortex. 2017 Jan 3.
doi: 10.1093/cercor/bhw406. [Epub ahead of print] PubMed PMID: 28052921.


2: Olesen MV, W÷rtwein G, Folke J, Pakkenberg B. Electroconvulsive stimulation
results in long-term survival of newly generated hippocampal neurons in rats.
Hippocampus. 2017 Jan;27(1):52-60. doi: 10.1002/hipo.22670. PubMed PMID:
27756104.


3: Reddy IA, Pino JA, Weikop P, Osses N, S°rensen G, Bering T, Valle C, Bluett
RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S,
Fink-Jensen A, Torres GE, Galli A. Glucagon-like peptide 1 receptor activation
regulates cocaine actions and dopamine homeostasis in the lateral septum by
decreasing arachidonic acid levels. Transl Psychiatry. 2016 May 17;6:e809. doi:
10.1038/tp.2016.86. PubMed PMID: 27187231; PubMed Central PMCID: PMC5070047.


4: S°rensen G, Reddy IA, Weikop P, Graham DL, Stanwood GD, Wortwein G, Galli A,
Fink-Jensen A. The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4
reduces cocaine self-administration in mice. Physiol Behav. 2015 Oct 1;149:262-8.
doi: 10.1016/j.physbeh.2015.06.013. PubMed PMID: 26072178; PubMed Central PMCID:
PMC4668599.


5: Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, S°rensen G, Andresen
B, Madsen KL, J°rgensen TN, W÷rtwein G, Woldbye DP, Sitte H, Daws LC, Gether U.
Membrane-permeable C-terminal dopamine transporter peptides attenuate
amphetamine-evoked dopamine release. J Biol Chem. 2013 Sep 20;288(38):27534-44.
doi: 10.1074/jbc.M112.441295. PubMed PMID: 23884410; PubMed Central PMCID:
PMC3779749.


6: Rickhag M, Hansen FH, S°rensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen
KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, FŘchtbauer
EM, Gomeza J, Woldbye DP, W÷rtwein G, Gether U. A C-terminal PDZ domain-binding
sequence is required for striatal distribution of the dopamine transporter. Nat
Commun. 2013;4:1580. doi: 10.1038/ncomms2568. Erratum in: Nat Commun.
2013;4:2589. PubMed PMID: 23481388; PubMed Central PMCID: PMC3646413.


7: Jorgensen A, Kalliokoski O, Forsberg K, Breitenstein K, Weimann A, Henriksen
T, Hau J, W÷rtwein G, Poulsen HE, Jorgensen MB. A chronic increase of
corticosterone age-dependently reduces systemic DNA damage from oxidation in
rats. Free Radic Biol Med. 2017 Mar;104:64-74. doi:
10.1016/j.freeradbiomed.2017.01.013. PubMed PMID: 28069523.


8: Elbr°nd-Bek H, Olling JD, G°tzsche CR, Waterfield A, W÷rtwein G, Woldbye DP.
Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the
hippocampus after kainate-induced seizures in mice. Synapse. 2014
Oct;68(10):427-36. doi: 10.1002/syn.21762. PubMed PMID: 24985894.


9: Jorgensen A, Maigaard K, W÷rtwein G, Hageman I, Henriksen T, Weimann A, M°ller
P, Loft S, Hau J, Poulsen HE, Jorgensen MB. Chronic restraint stress in rats
causes sustained increase in urinary corticosterone excretion without affecting
cerebral or systemic oxidatively generated DNA/RNA damage. Prog
Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:30-7. doi:
10.1016/j.pnpbp.2012.08.016. Erratum in: Prog Neuropsychopharmacol Biol
Psychiatry. 2015 Apr 3;58:105. PubMed PMID: 22960608.


10: Dencker D, Weikop P, S°rensen G, Woldbye DP, W÷rtwein G, Wess J, Fink-Jensen
A. An allosteric enhancer of M₄ muscarinic acetylcholine receptor function
inhibits behavioral and neurochemical effects of cocaine. Psychopharmacology
(Berl). 2012 Nov;224(2):277-87. doi: 10.1007/s00213-012-2751-8. PubMed PMID:
22648127; PubMed Central PMCID: PMC3914671.
Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
info@thebrainprize.org
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bj°rklund