Neuroscience in Denmark


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General information

Name (center, department, group or other)
Neuroimmunology (Owens) group, Neurobiology, SDU
Contact name
Trevor Owens
Contact email
towens#at#health#dot#sdu#dot#dk
Contact title
Professor
Date
22. September 2015
(Last edited: 1. March 2018)

Brief description of research activities

The Neuroimmunology group study pathogenic mechanisms of inflammatory diseases of the central nervous system (CNS), such as multiple sclerosis and neuromyelitis optica. Such mechanisms are often relevant to degenerative diseases such as Alzheimers disease. We mainly focus to mouse models and we use histological, flow cytometric, molecular and tissue culture methods to evaluate immuno- and neuropathogenesis in genetically-modified mice. We study interactions between the immune system and glial cells of the nervous system, both those that lead to pathology as well as with regulatory and protective outcomes. We are particularly interested in translating clinical observations to experimental analyses and we collaborate with groups in Region Syddanmark and OUH to understand how innate and adaptive immune cells and mediators contribute to neurological disease.

Keywords

MS, NMO, neuroinflammation, cytokines, myeloid cells, microglia

Research tools and techniques

Experimental models of neuroinflammation; flow cytometry; RT-qPCR; fluorescence/confocal microscopy

Scientific Personnel

No of Associate Professors/Postdocs: 4
No of PhD students: 4
Other: 4

Key references from within the last 5 years

Wlodarczyk A, Holtman IR, Krueger M, Yogev N, Bruttger J, Khorooshi, R, Benmamar-Badel, A, de Boer-Bergsma JJ, Martin,NA, Karram K, Kramer, I, Boddeke EWGM, Waisman A, Eggen BJL and Owens T. (2017). A novel microglial subset plays a key role in myelinogenesis in developing brain. EMBO J. doi: 10.15252/embj.201696056

Berg, CT, Khorooshi, R, Asgari, N. and Owens, T. (2017). Influence of Type I IFN signaling on anti-MOG antibody-mediated demyelination. J. Neuroinflammation 14:127.

CÚdile, O, ěsterby J°rgensen, L, Frank, I, Wlodarczyk, A and Owens, T. 2017. The chemokine receptor CCR2 maintains plasmacytoid dendritic cell homeostasis. Immunol Letts https://doi.org/10.1016/j.imlet.2017.10.012.

Wlodarczyk, A, CÚdile, O, Jensen, KN, Jasson, A, Mony, JT, Khorooshi, R, and Owens, T. 2015. Pathologic and protective roles for microglial subsets and bone marrow- and blood-derived myeloid cells in central nervous system inflammation. Frontiers in Immunology 6:463 doi: 10.3389/fimmu.2015.00463

Asgari N, Berg CT, M°rch MT, Khorooshi R, and Owens T. 2015. Cerebrospinal Fluid Aquaporin-4-IgG induces blood brain barrier breakdown. Ann Clin Trans Neurol, 2: 857-863 DOI: 101002/acn3221:n/a-n/a

Khorooshi, R., M°rch, M, Berg, CT, Holm, TH, Dieu, RT, DrŠby, D, Issazadeh-Navikas, S, Weiss, S, Lienenklaus, S and Owens, T. 2015. Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis. Acta Neuropathologica, 130:107-118.

CÚdile, O, L°bner, M, Toft-Hansen, H, Frank, I, Wlodarczyk, A, Irla, M, & Owens, T. 2014 Thymic CCL2 influences induction of T-cell tolerance. J Autoimmun 55:73-85.

Mony, JT, Khorooshi R, & Owens, T. 2014. Chemokine receptor expression by inflammatory T cells in EAE. Front. Cell. Neurosci. 8:187. doi: 10.3389/fncel.2014.00187.

Wlodarczyk, A., L°bner, M., CÚdile, O., and Owens, T. 2014. Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response. J Neuroinflammation 11:57-65.

Mony JT, Khorooshi R, Owens T. 2014. MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE. MS Journal 20:1312-1321.
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2100 Copenhagen Ø
Denmark
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CVR-nr. 11 81 49 13
thebrainprize@lundbeckfonden.com
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bj°rklund