Neuroscience in Denmark


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General information

Name (center, department, group or other)
Lauritzen lab, Translational Neurobiology, University of Copenhagen
Contact name
Martin J Lauritzen
Contact email
mlauritz#at#sund#dot#ku#dot#dk
Contact title
Professor
Date
28. September 2015


Brief description of research activities

At the Department of Neuroscience and Pharmacology at the University of Copenhagen, the Laboratory of Translational Neurobiology (LTN) aims to understand how the brain controls its own blood supply and use, and the transport of molecules across the blood-brain-barrier. The new knowledge generated in the lab can be used to understand the general pathophysiology of a number of human brain diseases and conditions including ageing, stroke, migraine and intracerebral and subarachnoid hemorrhage.

Important milestones at the Laboratory of Translational Neurobiology
Among others the LTN has achieved the following milestones:
• Implementation of two-photon microscopy for use in living rodents
• Implementation of optogenetics for use in living rodents
• Implementation of genetically encoded indicators for assessment of nerve cell activity by 2-photon microscope
• Generation of mouse models for ageing, migraine, stroke and brain hemorrhages
• Novel findings about vascular control by calcium signals in the neurovascular unit and in brain vascular pericytes was published recently.

The LTN takes part in and are leading the Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery (RIBBDD) and has developed new models to assess drug delivery to the brain.

Network and collaborators at the Laboratory of Translational Neurobiology
The group has ongoing collaboration with researchers including, but not limited to, University of British Columbia, Vancouver, Canada; the MIRCen, Paris, France; Moscow State University with Klinikum Charite, Berlin, Germany, and with scientists at national universities.


Research tools and techniques

In vivo physiology.
Classic electrophysiology.
Two-photon imaging.
Blood flow and oxygen measurements.
Mouse disease models.

Scientific Personnel

No of Associate Professors/Postdocs: 7
No of PhD students: 4
Other: 4

Key references from within the last 5 years

1 Ayata C, Lauritzen M: Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev 2015;95:953-993.
2 Jessen SB, Brazhe A, Lind BL, Mathiesen C, Thomsen K, Jensen K, Lauritzen M: GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo. Cereb Cortex 2015;25:2594-2609.
3 Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D: Capillary pericytes regulate cerebral blood flow in health and disease. Nature 2014;508:55-60.
4 Mathiesen C, Brazhe A, Thomsen K, Lauritzen M: Spontaneous calcium waves in Bergman glia increase with age and hypoxia and may reduce tissue oxygen. J Cereb Blood Flow Metab 2013;33:161-169.
5 Lind BL, Brazhe AR, Jessen SB, Tan FC, Lauritzen MJ: Rapid stimulus-evoked astrocyte Ca2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo. Proc Natl Acad Sci U S A 2013;110:E4678-E4687.


Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
info@thebrainprize.org
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund