Neuroscience in Denmark


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General information

Name (center, department, group or other)
Dandrite - Danish Research Institute of Translational Neuroscience, Department of Biomedicine, Neurodegenerative Disease Laboratory, Aarhus University
Contact name
Poul Henning Jensen
Contact email
phj#at#biomed#dot#au#dot#dk
Contact title
professor
Date
7. October 2015


Brief description of research activities

Our group is interested in understanding how alpha-synuclein contributes to the neurodegenerative processes in Parkinson’s disease, Lewy body dementia and multiple systems atrophy, which are hallmarked by the development of intracellular aggregates of alpha-synuclein. The aim is to decipher how cells regulate their pools of alpha-synuclein species and how they respond to misfolded alpha-synuclein with respect to cytotoxic and protective mechanisms that can be targeted by therapy. This involves proteostatic mechanisms like autophagy, unconventional secretion, prion-like intercellular propagation and homeostatic cellular mechanisms being offset by alpha-synuclein aggregates.
Currently specific projects focuses on alpha-synucleins role in calcium regulation, kinase pathways regulating alpha-synuclein turn-over and toxicity, relation to the innate immune system and implementation of a mouse model for prion-like spreading of alpha-synuclein brain pathology.

Keywords: Neurodegeneration, Parkinson's disease, dementia, alpha-synuclein, amyloid, kinases, calcium, disease modeling, prion-like

Research tools and techniques

Cell and animal disease modeling; protein chemistry; cell biology; molecular biology; fluorescence microscopy;

Scientific Personnel

No of Associate Professors/Postdocs: 3
No of PhD students: 3
Other: 4

Key references from within the last 5 years

• Betzer C, Movius AJ, Shi M , Zhang J, Jensen PH (2015) Identification of Alpha-Synuclein Interacting Synaptosomal Proteins. Plos One, 10(2):e0116473.
• Kragh CL, Gysbers AM, Rockenstein E, Murphy K, Halliday GM, Masliah E, Jensen PH (2014) Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy. Neurobiol of Disease, 2014 63:171-83
• Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein B, Madiona K, Olieric V, Böckmann A, Meier BH, Melki R. (2013) Structural and functional characterization of two alpha-synuclein strains. Nat Commun. 4:2575.
• Mysling S, Betzer C, Jensen PH, Jorgensen TJD (2013) Characterizing the dynamics of alpha-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry. Biochemistry, 52:9097-103
• Kragh CL, Fillon G, Amanda Cysbers, Hansen HD, Neumann M, Gai W-P, Richter-Landsberg C, Haass C, Zalc, B, Lubetzki C, Gai, W-P, Halliday, G, Kahle PJ, Jensen PH (2013) Fas-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy, PlosOne, 8(1):e55243.
• Ejlerskov P, Rasmussen I, Nielsen TT, Bergström A-L, Tohyama Y, Jensen PH, Vilhardt F (2013) Tubulin Polymerization Promoting Protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion J Biol Chem 288(24):17313-35
• Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK (2012) Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J. Neurosci., 32: 3301-5
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Denmark
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info@thebrainprize.org
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