Neuroscience in Denmark

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General information

Name (center, department, group or other)
Dandrite - Danish Research Institute of Translational Neuroscience, Department of Biomedicine, Neurodegenerative Disease Laboratory, Aarhus University
Contact name
Poul Henning Jensen
Contact email
Contact title
7. October 2015

Brief description of research activities

Our group is interested in understanding how alpha-synuclein contributes to the neurodegenerative processes in Parkinson’s disease, Lewy body dementia and multiple systems atrophy, which are hallmarked by the development of intracellular aggregates of alpha-synuclein. The aim is to decipher how cells regulate their pools of alpha-synuclein species and how they respond to misfolded alpha-synuclein with respect to cytotoxic and protective mechanisms that can be targeted by therapy. This involves proteostatic mechanisms like autophagy, unconventional secretion, prion-like intercellular propagation and homeostatic cellular mechanisms being offset by alpha-synuclein aggregates.
Currently specific projects focuses on alpha-synucleins role in calcium regulation, kinase pathways regulating alpha-synuclein turn-over and toxicity, relation to the innate immune system and implementation of a mouse model for prion-like spreading of alpha-synuclein brain pathology.

Keywords: Neurodegeneration, Parkinson's disease, dementia, alpha-synuclein, amyloid, kinases, calcium, disease modeling, prion-like

Research tools and techniques

Cell and animal disease modeling; protein chemistry; cell biology; molecular biology; fluorescence microscopy;

Scientific Personnel

No of Associate Professors/Postdocs: 3
No of PhD students: 3
Other: 4

Key references from within the last 5 years

• Betzer C, Movius AJ, Shi M , Zhang J, Jensen PH (2015) Identification of Alpha-Synuclein Interacting Synaptosomal Proteins. Plos One, 10(2):e0116473.
• Kragh CL, Gysbers AM, Rockenstein E, Murphy K, Halliday GM, Masliah E, Jensen PH (2014) Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy. Neurobiol of Disease, 2014 63:171-83
• Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein B, Madiona K, Olieric V, Böckmann A, Meier BH, Melki R. (2013) Structural and functional characterization of two alpha-synuclein strains. Nat Commun. 4:2575.
• Mysling S, Betzer C, Jensen PH, Jorgensen TJD (2013) Characterizing the dynamics of alpha-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry. Biochemistry, 52:9097-103
• Kragh CL, Fillon G, Amanda Cysbers, Hansen HD, Neumann M, Gai W-P, Richter-Landsberg C, Haass C, Zalc, B, Lubetzki C, Gai, W-P, Halliday, G, Kahle PJ, Jensen PH (2013) Fas-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy, PlosOne, 8(1):e55243.
• Ejlerskov P, Rasmussen I, Nielsen TT, Bergström A-L, Tohyama Y, Jensen PH, Vilhardt F (2013) Tubulin Polymerization Promoting Protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion J Biol Chem 288(24):17313-35
• Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK (2012) Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J. Neurosci., 32: 3301-5
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