Neuroscience in Denmark


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General information

Name (center, department, group or other)
Glerup Lab, Department of Biomedicine, Aarhus University
Contact name
Simon Glerup
Contact email
glerup#at#biomed#dot#au#dot#dk
Contact title
Associate Professor
Date
2. December 2015
(Last edited: 28. March 2018)

Brief description of research activities

Neurons of the developing brain respond to the extracellular environment in a polarized manner thereby securing the correct neuronal positioning and connectivity in the adult brain. The precise regulation of these processes during development remains poorly understood, but enable us as adults to think, remember, and perceive reality in a normal manner. Their breakdown, on the other hand, manifests itself as neurological and mental disorders. My group is particularly interested in a family of sorting receptors, sortilins, which appear to have evolutionary conserved roles in the establishment and maintenance of neuronal circuits. Our focus is to determine the role of individual sortilins in distinct neuronal systems and how their dysfunction contributes to neurological and mental disorders. To study this, we employ a translational strategy using transgenic animal models, in utero electroporation, confocal microscopy, behavioural and molecular neurobiology in addition to genetic and biochemical analysis of patient samples.

Keywords

sortilins, mental disorders, neurological disorders, animal behavior, neuronal development

Research tools and techniques

molecular neurobiology
in utero electroporation
mouse behavior

Scientific Personnel

No of Associate Professors/Postdocs: 7
No of PhD students: 5
Other: 8

Key references from within the last 5 years

(1) Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment
Simon Bøggild, Simon Mølgaard, Simon Glerup, Jens R. Nyengaard
Journal of Comparative Neurology 2018 Feb 6

(2) Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
Camilla Gustafsen, Ditte Olsen, Signe L. Jensen, Joachim Vilstrup, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-Ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup
Nature Communications 2017 Sep 11;8(1):503

(3) SorCS2 is required for BDNF dependent plasticity in the hippocampus
Simon Glerup, Ulrik Bolcho, Simon Mølgaard, Simon Bøggild, Christian B. Vaegter, Andrew H. Smith, Jose Luis Nieto-Gonzales, Peter Lund Ovesen, Lone F. Pedersen, Anja N. Fjorback, Mads Kjolby, Hande Login, Mai Marie Holm, Olav M. Andersen, Jens R. Nyengaard, Thomas E. Willnow, Kimmo Jensen, Anders Nykjaer
Molecular Psychiatry (2016) Dec;21(12):1740-1751

(4) Whole-exome sequencing reveals increased burden of rare functional and disruptive variants in candidate risk genes in individuals with adult ADHD
Ditte Demontis, Søren Dinesen Østergaard, Li Qibin, Jieqin Liang, Francesco Lescai, Klaus-Peter Lesch, Hui Jiang, Andreas Reif, Jan K. Buitelaar, Li Yingrui, Ole Mors, Wang Jun, Barbara Franke, Anders Børglum, Simon Glerup
Journal of American Academy of Child and Adolescent Psychiatry (2016) Jun;55(6):521-3

(5) Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF
Henriette N. Buttenschøn, Ditte Demontis, Mathias Kaas, Betina Elfving, Simon Mølgaard, Camilla Gustafsen, Linda Kaerlev, Claus M. Petersen, Anders D. Børglum, Ole Mors, Simon Glerup
Translational Psychiatry (2015) Nov 10

(6) SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia
Simon Glerup, Ditte Olsen, Christian Vaegter, Camilla Gustafsen, Susanne Sjoegaard, Guido Hermey, Mads Kjolby, Simon Molgaard, Maj Ulrichsen, Simon Boggild, Sune Skeldal, Anja Fjorback, Jens Nyengaard, Jan Jacobsen, Dirk Bender, Carsten Bjarkam, Esben Sørensen, Gregor Eichele, Peder Madsen, Ernst-Martin Füchtbauer, Thomas E. Willnow, Claus M. Petersen, Anders Nykjær
Neuron (2014) Jun 4;82(5):1074-87

(7) The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion
Camilla Gustafsen, Mads Kjolby, Mette Nyegaard, Manuel Mattheisen, Jesper Lundhede, Henriette Buttenschøn, Ole Mors, Jacob F. Bentzon, Peder Madsen, Anders Nykjaer, Simon Glerup
Cell Metabolism (2014) Feb 4;19(2):310-8

(8) Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition
Ditte Olsen, Mathias Kaas, Ole Schwartz, Anders Nykjær, Simon Glerup
Learning & Memory (2013) Sep 1;20(9):499-504

(9) SorLA controls neurotrophic activity by sorting of GDNF and its receptor GFRα1 and RET
Simon Glerup, Maria Lume, Ditte Olsen, Jens Nyengaard, Christian Vægter, Camilla
Gustafsen, Erik I. Christensen, Mads Kjolby, Anders Hay-Schmidt, Dirk Bender, Peder Madsen,
Mart Saarma, Anders Nykjær, Claus M. Petersen
Cell Reports (2013) Jan 31.(3) 1-14

(10) Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein
Camilla Gustafsen, Simon Glerup, Lone T. Pallesen, Ditte Olsen, Olav M. Andersen, Anders Nykjær, Peder Madsen, Claus M. Petersen
Journal of Neuroscience (2013) Jan 2;33(1):64-71


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