Neuroscience in Denmark


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General information

Name (center, department, group or other)
Glerup Lab, Department of Biomedicine, Aarhus University
Contact name
Simon Glerup
Contact email
glerup#at#biomed#dot#au#dot#dk
Contact title
Associate Professor
Date
2. December 2015


Brief description of research activities

Neurons of the developing brain respond to the extracellular environment in a polarized manner thereby securing the correct neuronal positioning and connectivity in the adult brain. The precise regulation of these processes during development remains poorly understood, but enable us as adults to think, remember, and perceive reality in a normal manner. Their breakdown, on the other hand, manifests itself as mental disorders. My group is particularly interested in a family of sorting receptors, sortilins, which appear to have evolutionary conserved roles in the establishment and maintenance of neuronal circuits. Our focus is to determine the role of individual sortilins in distinct neuronal systems and how their dysfunction contributes to the behavioural phenotypes observed in psychiatric patients. To study this, we employ a translational strategy using transgenic animal models, in utero electroporation, confocal microscopy, behavioural and molecular neurobiology in addition to genetic and biochemical analysis of patient samples.
Keywords: sortilins, mental disorders, animal behavior, neuronal development

Research tools and techniques

molecular neurobiology
in utero electroporation
mouse behavior

Scientific Personnel

No of Associate Professors/Postdocs: 5
No of PhD students: 1
Other: 4

Key references from within the last 5 years

(1) Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF
Henriette N. Buttenschøn, Ditte Demontis, Mathias Kaas, Betina Elfving, Simon Mølgaard, Camilla Gustafsen, Linda Kaerlev, Claus M. Petersen, Anders D. Børglum, Ole Mors, Simon Glerup
Translational Psychiatry (2015) Nov 10

(2) SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia
Simon Glerup, Ditte Olsen, Christian Vaegter, Camilla Gustafsen, Susanne Sjoegaard, Guido Hermey, Mads Kjolby, Simon Molgaard, Maj Ulrichsen, Simon Boggild, Sune Skeldal, Anja Fjorback, Jens Nyengaard, Jan Jacobsen, Dirk Bender, Carsten Bjarkam, Esben Sørensen, Gregor Eichele, Peder Madsen, Ernst-Martin Füchtbauer, Thomas E. Willnow, Claus M. Petersen, Anders Nykjær
Neuron (2014) Jun 4;82(5):1074-87

(3) The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion
Camilla Gustafsen, Mads Kjolby, Mette Nyegaard, Manuel Mattheisen, Jesper Lundhede, Henriette Buttenschøn, Ole Mors, Jacob F. Bentzon, Peder Madsen, Anders Nykjaer, Simon Glerup
Cell Metabolism (2014) Feb 4;19(2):310-8

(4) Sortilins as regulators of neurotrophic factor signaling
Simon Glerup, Anders Nykjær, Christian Vægter
Handbook of Experimental Pharmacology (2014) 220:165-89

(5) Sortilin-related receptor SorCS3 is postsynaptic modulator of synaptic depression and fear extinction
Tilman Breiderhoff, Gitte B. Christiansen, Lone T. Pallesen, Christian Vægter, Anders Nykjær, Mai M. Holm, Simon Glerup, and Thomas Willnow
PLoS ONE (2013) Sep 19; 8(9): e75006

(6) Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition
Ditte Olsen, Mathias Kaas, Ole Schwartz, Anders Nykjær, Simon Glerup
Learning & Memory (2013) Sep 1;20(9):499-504

(7) SorLA controls neurotrophic activity by sorting of GDNF and its receptor GFRα1 and RET
Simon Glerup, Maria Lume, Ditte Olsen, Jens Nyengaard, Christian Vægter, Camilla
Gustafsen, Erik I. Christensen, Mads Kjolby, Anders Hay-Schmidt, Dirk Bender, Peder Madsen,
Mart Saarma, Anders Nykjær, Claus M. Petersen
Cell Reports (2013) Jan 31.(3) 1-14

(8) Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein
Camilla Gustafsen, Simon Glerup, Lone T. Pallesen, Ditte Olsen, Olav M. Andersen, Anders Nykjær, Peder Madsen, Claus M. Petersen
Journal of Neuroscience (2013) Jan 2;33(1):64-71


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