Neuroscience in Denmark


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General information

Name (center, department, group or other)
The Danish Research Centre for Magnetic Resonance (DRCMR)
Contact name
Hartwig R. Siebner
Contact title
Professor, Head of Research DRCMR
Date
25. January 2016


Brief description of research activities

The Danish Research Centre for Magnetic Resonance (DRCMR) houses a multidisciplinary and multinational research team with expertise within four main research areas:
Neurostimulation & Imaging
Lifespan Imaging
Highfield MR, Physics & Analysis
Cognitive & Clinical Neuroscience

DRCMR has a methodological line of research which aims at advancing biomedical use of MRI and a more applied line of research which is geared to conduct ground-breaking basic and clinical neuroscience.
Researchers at DRCMR strive to deliver the best research and education oriented towards understanding how brain disorders affect brain structure, function, and metabolism. This knowledge will promote early diagnosis and monitoring, but also yield novel insight into disease mechanisms and how the brain is able to cope with damage.
The centre’s research activities range from the development of new hardware, software, and analyses methods through research that leads to a better biological understanding of the healthy human body all the way to clinical research. Across different research areas, we have become increasingly successful in combining multiple imaging modalities, non-invasive brain stimulation techniques and computational methods to address neuroscientific questions. Furthermore, work is focused on selecting the appropriate modality to the specific purpose as well as developing computational methods that integrate MRI and other methodologies to generate synergistic value. The center is imbedded at Hvidovre hospital and houses three 3T MRIs and the first 7T MR whole-body system for human use in Denmark. Additional facilities include a pre-clincal MR facility, a MR-simulator suite as well as laboratories for transcranial magnetic stimulation (TMS) and electroencephalography (EEG).
The research at DRCMR is concentrated around the four main research areas mentioned above and structured into more than 15 research groups with one or multiple research group leaders. The responsibilities of the group leaders include developing a strategy and infrastructure within their research areas as well as project management and fundraising.

Distribution of groups within the four main research areas:

Neurostimulation & Imaging: Basics (Biophysically Adjusted State Informed Cortex Stimulation), Integrative Neurostimulation and Neuroimaging, Computational modelling and analysis group, EEG Group

Lifespan Imaging: Brain Maturation Group, Ageing and Dementia

High-field MR, Physics & Analysis: Cardiovascular Imaging Unit, The Preclinical Research Group, Hyperpolarized MRI, MR Physics and Acquisition, Ultra-high field MRI, Diffusion Imaging Group, Computational modelling and analysis group

Cognitive & Clinical Neuroscience: ContAct (Control of Action), Reward and Homeostasis, Ageing and Dementia, Neuroimaging in Multiple Sclerosis, Neuroimaging of Movement Disorders, Traumatic Brain Injury, Electroencephalography (EEG) Group

Keywords

MRI
Data processing
Preclinical research
Motor control
Cognitive neuroscience
Interventional neurophysiology
Transcranial stimulation
Multimodal integration
Neurology and psychiatry


Research tools and techniques

Structural, functional and neurochemical MRI
Transcranial Magnetic Stimulation and other non-invasive transcranial stimulation techniques (TACS, TDCS)
Electroencephalography
Behavioral assessments
Computational modelling


Scientific Personnel

No of Associate Professors/Postdocs: 26
No of PhD students: 31
Other: 30

Key references from within the last 5 years

Dogonowski AM*, Andersen KW*, Madsen KH, Soelberg Sørensen P, Paulson OB, Blinkenberg M, Siebner HR (2013) Multiple sclerosis impairs regional functional connectivity in the cerebellum. Neuroimage Clinical 4:130-108. (* shared first authorship)

Andersen KW, Madsen KH, Siebner HR, Schmidt MN, Mørup M, Hansen LK (2014) Non-parametric Bayesian graph models reveal community structure in resting state fMRI. NeuroImage 100:301-315.

Dyrby TB, Lundell L, Burke MW, Reislev NL, Paulson OB, Ptito M, Siebner HR (2014) Interpolation of diffusion weighted imaging datasets. NeuroImage 103:202-213.

Herz DM, Haagensen BN, Christensen MS, Madsen KH, Rowe J, Løkkegaard A, Siebner HR (2014) The acute brain response to levodopa heralds dyskinesias in Parkinson’s disease. Ann Neurol 75:829-836.

Hulme OJ, Skov M, Chadwick M, Siebner HR, Ramsøy TZ (2014) Sparse encoding of automatic visual association in hippocampal networks. NeuroImage 102P2:458-464.

Macoveanu J, Miskowiak K, Vinberg M, Kessing LV, Siebner HR (2014) Healthy co-twins of patients with affective disorders show reduced insula response to risky choices. NeuroImage 99:434-442.

Gelskov SV, Henningsson S, Madsen KH, Siebner HR*, Ramsøy TZ* (* equal contribution) 2015 Amygdala signals subjective appetitiveness and aversiveness of mixed gambles. Cortex. 66:81-90.

Henningsson S, Madsen HC, Pinborg A, Heede M, Knudsen GM, Siebner HR, Frokjaer VG (2015) Role of emotional processing in depressive responses to sex-hormone manipulation; a pharmacological fMRI study. Transl Psychiatry 5:e688.

Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR (2015) Effects of erythropoietin on hippocampal volume and memory in mood disorder: a randomized, placebo-controlled study. Biol Psychiat 8:270-277.

Raffin E*, Pellegrino G*, Di Lazzaro V, Thielscher A, Siebner HR (2015) Bringing transcranial mapping into shape: Sulcus-aligned mapping captures motor somatotopy in human primary motor hand area. NeuroImage 120:164–175. * Shared first authors.

Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
info@thebrainprize.org
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund