Neuroscience in Denmark


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General information

Name (center, department, group or other)
The Danish Research Centre for Magnetic Resonance (DRCMR)
Contact name
Hartwig R. Siebner
Contact title
Professor, Head of Research DRCMR
Date
25. January 2016
(Last edited: 1. March 2018)

Brief description of research activities

At The Danish Research Centre for Magnetic Resonance (DRCMR) our VISION is to map brain dynamics to promote health and to tailor therapy. We use advanced magnetic resonance imaging to create knowledge about the brain – knowledge that can be used to optimize treatments in individual patients and to boost public and individual health, potential, and well-being. And our MISSION is to use brain mapping to unravel causal dynamics in the human brain. We study beneficial brain dynamics that secure physical and mental health as well as detrimental brain dynamics that cause brain disorders across the lifespan.
DRCMR has a methodological line of research which aims at advancing biomedical use of MRI and a more applied line of research which is geared to conduct ground-breaking basic and clinical neuroscience.
Researchers at DRCMR strive to deliver the best research and education oriented towards understanding how brain disorders affect brain structure, function, and metabolism. This knowledge will promote early diagnosis and monitoring, but also yield novel insight into disease mechanisms and how the brain is able to cope with damage.
The centre’s research activities range from the development of new hardware, software, and analyses methods through research that leads to a better biological understanding of the healthy human body all the way to clinical research. Across different research areas, we have become increasingly successful in combining multiple imaging modalities, non-invasive brain stimulation techniques and computational methods to address neuroscientific questions. Furthermore, work is focused on selecting the appropriate modality to the specific purpose as well as developing computational methods that integrate MRI and other methodologies to generate synergistic value. The center is imbedded at Hvidovre hospital and houses three 3T MRIs and the first 7T MR whole-body system for human use in Denmark. Additional facilities include a pre-clincal MR facility, a MR-simulator suite as well as laboratories for transcranial magnetic stimulation (TMS) and electroencephalography (EEG).

DRCMR houses 13 multidisciplinary and multinational research groups with expertise within FIVE MAIN RESERACH AREAS and divided into 13 research Groups.
MR PHYSICS & ANALYSIS: Microstructure and Plasticity, High Field 7T MR, Acquisition Technology
TRANSCRANIAL BRAIN STIMULATION: Interventional Neurophysiology, Neurophysics
COGNITIVE & COMPUTATIONAL NEUROSCIENCE: Computational Neuromaging, Reward & Homeostasis, Motor Control
LIFESPAN IMAGING: Healthy Ageing, Brain Maturation
CLINICAL IMAGING: Movement Disorders, Multiple Sclerosis, Traumatic Brain Injury

In addition to the research groups we also house five method groups: MR Methodology, Preclinical, Brain Stimulation, EEG, fMRI

Keywords

MRI
Data processing
Preclinical research
Motor control
Cognitive neuroscience
Interventional neurophysiology
Transcranial stimulation
Lifespan
Neurology and psychiatry


Research tools and techniques

Structural, functional and neurochemical MRI
Transcranial Magnetic Stimulation and other non-invasive transcranial stimulation techniques (TACS, TDCS)
Electroencephalography
Behavioral assessments
Computational modelling


Scientific Personnel

No of Associate Professors/Postdocs: 30
No of PhD students: 24
Other: 31

Key references from within the last 5 years

Dogonowski AM*, Andersen KW*, Madsen KH, Soelberg Sørensen P, Paulson OB, Blinkenberg M, Siebner HR (2013) Multiple sclerosis impairs regional functional connectivity in the cerebellum. Neuroimage Clinical 4:130-108. (* shared first authorship)

Andersen KW, Madsen KH, Siebner HR, Schmidt MN, Mørup M, Hansen LK (2014) Non-parametric Bayesian graph models reveal community structure in resting state fMRI. NeuroImage 100:301-315.

Dyrby TB, Lundell L, Burke MW, Reislev NL, Paulson OB, Ptito M, Siebner HR (2014) Interpolation of diffusion weighted imaging datasets. NeuroImage 103:202-213.

Herz DM, Haagensen BN, Christensen MS, Madsen KH, Rowe J, Løkkegaard A, Siebner HR (2014) The acute brain response to levodopa heralds dyskinesias in Parkinson’s disease. Ann Neurol 75:829-836.

Hulme OJ, Skov M, Chadwick M, Siebner HR, Ramsøy TZ (2014) Sparse encoding of automatic visual association in hippocampal networks. NeuroImage 102P2:458-464.

Macoveanu J, Miskowiak K, Vinberg M, Kessing LV, Siebner HR (2014) Healthy co-twins of patients with affective disorders show reduced insula response to risky choices. NeuroImage 99:434-442.

Gelskov SV, Henningsson S, Madsen KH, Siebner HR*, Ramsøy TZ* (* equal contribution) 2015 Amygdala signals subjective appetitiveness and aversiveness of mixed gambles. Cortex. 66:81-90.

Henningsson S, Madsen HC, Pinborg A, Heede M, Knudsen GM, Siebner HR, Frokjaer VG (2015) Role of emotional processing in depressive responses to sex-hormone manipulation; a pharmacological fMRI study. Transl Psychiatry 5:e688.

Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR (2015) Effects of erythropoietin on hippocampal volume and memory in mood disorder: a randomized, placebo-controlled study. Biol Psychiat 8:270-277.

Raffin E*, Pellegrino G*, Di Lazzaro V, Thielscher A, Siebner HR (2015) Bringing transcranial mapping into shape: Sulcus-aligned mapping captures motor somatotopy in human primary motor hand area. NeuroImage 120:164–175. * Shared first authors.

Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
thebrainprize@lundbeckfonden.com
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund