Neuroscience in Denmark


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General information

Name (center, department, group or other)
Molecular Neurobiology group, Institute of Molecular Medicine, Univeristy of Southern Denmark
Contact name
Eirikur Benedikz and Åsa Fex Svenningsen
Contact email
ebenedikz#at#health#dot#sdu#dot#dk, aasvenningsen#at#health#dot#sdu#dot#dk
Contact title
Associate Professors
Date
5. April 2016


Brief description of research activities

The focus of our research is mainly on two areas:
1) Neurodevelopmental disorders such as schizophrenia where we investigate protein-protein interactions in the central nervous system in health and disease. Many human diseases can be traced to aberrant protein–protein interactions, either through the loss of an essential interaction or through the formation of a protein complex at an inappropriate time or location.
2) Glial cell biology both in the central and peripheral nervous system with a focus on Multiple sclerosis but also nerve regeneration.


Keywords

Schizophrenia, Multiple Sclerosis, Cell biology, Protein-protein interactions, functional protein analysis, protein expression

Research tools and techniques

BioID, Yeast two-hybrid, brain cell cultures, cell functional studies, protein expression

Scientific Personnel

No of Associate Professors/Postdocs: 4
No of PhD students: 3
Other: 6

Key references from within the last 5 years

The Rat Homolog of the Schizophrenia Susceptibility Gene ZNF804A Is Highly Expressed during Brain Development, Particularly in Growth Cones. Hinna KH, Rich K, Fex-Svenningsen Å, Benedikz E. PLoS One. 2015 Jul 6;10(7):e0132456

GABA and its B-receptor are present at the node of Ranvier in a small population of sensory fibers, implicating a role in myelination. Corell M, Wicher G, Radomska KJ, Dağlıkoca ED, Godskesen RE, Fredriksson R, Benedikz E, Magnaghi V, Fex Svenningsen A. J Neurosci Res. 2015 Feb;93(2):285-95

Oxaliplatin-induced neuropathy in colorectal cancer: many questions with few answers. Zedan AH, Hansen TF, Fex Svenningsen A, Vilholm OJ. Clin Colorectal Cancer. 2014 Jun;13(2):73-80

Agholme L, Hallbeck M, Benedikz E, Marcusson J, Kågedal K. Amyloid-β Secretion, Generation, and Lysosomal Sequestration in Response to Proteasome Inhibition: Involvement of Autophagy. J Alzheimers Dis. 2012 31(2):343-58

Zheng L, Terman A, Hallbeck M, Dehvari N, Cowburn RF, Benedikz E, Kågedal K, Cedazo-Minguez A, Marcusson J. Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells. Autophagy 2011 7 (12):1528-45

MALDI mass spectrometry based molecular phenotyping of CNS glial cells for prediction in mammalian brain tissue. Hanrieder J, Wicher G, Bergquist J, Andersson M, Fex-Svenningsen A. Anal Bioanal Chem. 2011 Jul;401(1):135-47

Effects on DHEA levels by estrogen in rat astrocytes and CNS co-cultures via the regulation of CYP7B1-mediated metabolism. Fex Svenningsen A, Wicher G, Lundqvist J, Pettersson H, Corell M, Norlin M. Neurochem Int. 2011 May;58(6):620-4

Eriksson M, Samuelsson H, Björklund S, Tortosa E, Avila J, Samuelsson E-B, Benedikz E, Sundström E. MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations. Neurosci Lett. 2010 475(1): 33-7

MDMA (Ecstasy) decreases the number of neurons and stem cells in embryonic cortical cultures. Kindlundh-Högberg AM, Pickering C, Wicher G, Hobér D, Schiöth HB, Fex Svenningsen A. Cell Mol Neurobiol. 2010 Jan;30(1):13-21

Kloskowska E, Pham TM, Nilsson T, Zhu S, Öberg J, Codita A, Pedersen LØ, Pedersen JT, Malkiewicz K, Winblad B, Folkesson R, Benedikz E. Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer’s disease. J Mol Cell Med. 2010 14(6b): 1816-23.
Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
info@thebrainprize.org
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund