Neuroscience in Denmark


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General information

Name (center, department, group or other)
Center for Experimental Neuroscience - CENSE, Department of Neurosurgery, Aarhus Universityhospital, www.cense.dk
Contact name
Jens Christian Hedemann Sørensen
Contact email
jenssore#at#rm#dot#dk
Contact title
Professor, MD, PhD, DMSc
Date
31. July 2016
(Last edited: 1. March 2017)

Brief description of research activities

Center for Experimental Neurosciense (CENSE) at the Department of Neurosurgery and the Danish Neuroscience Center focuses on large animal research, specifically on the Göttingen minipig, for developing models of neurologic and psychiatric diseases. The brain of the minipig has a large degree of homology to the human brain and is sufficiently large for the use of human sized implant materials, neuromodulation devices, new medicine and stem cells for preclinical testing. CENSE has developed new anatomical atlases and MRI-guided stereotaxic equipment for placement of electrodes and neuromodulatory devices in the central nervous system, including the spinal cord. This includes the neurosurgical techniques as well as high TESLA MRI, PET and CT to test in vivo function. The group has also developed histopathology techniques for brain extraction and exact sectioning of brain sections in relation to scanning modalities and stereology purposes. Our procedures are performed according to GLP standards and conform to Aarhus University’s Animal Welfare Policy.

Find more info at: http://www.cense.dk/



Keywords

Translational neuroscience, large animal models, minipigs, neurosurgery, neuromodulation, neuronavigation, neurobiology, neuroanatomy, neurohistology, stereology,

Research tools and techniques

Minipig models, Stereotaxic Neurosurgery, MRI, PET, Neurohistology

Scientific Personnel

No of Associate Professors/Postdocs: 8
No of PhD students: 5
Other: 5

Key references from within the last 5 years

1: Orlowski D, Michalis A, Glud AN, Korshøj AR, Fitting LM, Mikkelsen TW,
Mercanzini A, Jordan A, Dransart A, Sørensen JC. Brain Tissue Reaction to Deep
Brain Stimulation-A Longitudinal Study of DBS in the Goettingen Minipig.
Neuromodulation. 2017 Feb 21. doi: 10.1111/ner.12576. [Epub ahead of print]
PubMed PMID: 28220987.


2: Meidahl AC, Orlowski D, Sørensen JC, Bjarkam CR. The Retrograde Connections
and Anatomical Segregation of the Göttingen Minipig Nucleus Accumbens. Front
Neuroanat. 2016 Dec 5;10:117. PubMed PMID: 27994542; PubMed Central PMCID:
PMC5136552.


3: Meier K, Bendtsen TF, Sørensen JC, Nikolajsen L. Peripheral Neuromodulation
for the Treatment of Postamputation Neuroma Pain: A Case Report. A A Case Rep.
2017 Jan 15;8(2):29-30. doi: 10.1213/XAA.0000000000000413. PubMed PMID: 27828784.


4: Bjarkam CR, Glud AN, Orlowski D, Sørensen JC, Palomero-Gallagher N. The
telencephalon of the Göttingen minipig, cytoarchitecture and cortical surface
anatomy. Brain Struct Funct. 2016 Oct 24. [Epub ahead of print] PubMed PMID:
27778106.


5: Korshoej AR, Saturnino GB, Rasmussen LK, von Oettingen G, Sørensen JC,
Thielscher A. Enhancing Predicted Efficacy of Tumor Treating Fields Therapy of
Glioblastoma Using Targeted Surgical Craniectomy: A Computer Modeling Study. PLoS
One. 2016 Oct 3;11(10):e0164051. doi: 10.1371/journal.pone.0164051. PubMed PMID:
27695068; PubMed Central PMCID: PMC5047456.


6: Nielsen MS, Glud AN, Møller A, Mogensen P, Bender D, Sørensen JC, Doudet D,
Bjarkam CR. Continuous MPTP intoxication in the Göttingen minipig results in
chronic parkinsonian deficits. Acta Neurobiol Exp (Wars). 2016;76(3):199-211.
PubMed PMID: 27685773.


7: Glud AN, Bjarkam CR, Azimi N, Johe K, Sorensen JC, Cunningham M. Feasibility
of Three-Dimensional Placement of Human Therapeutic Stem Cells Using the
Intracerebral Microinjection Instrument. Neuromodulation. 2016 Oct;19(7):708-716.
doi: 10.1111/ner.12484. Erratum in: Neuromodulation. 2016 Dec;19(8):904. PubMed
PMID: 27593216.


8: Jensen TS, Carlsen JG, Sørensen JC, Poulsen FR. Fewer complications with
bolt-connected than tunneled external ventricular drainage. Acta Neurochir
(Wien). 2016 Aug;158(8):1491-4. doi: 10.1007/s00701-016-2863-8. PubMed PMID:
27324657.


9: Langhorn L, Holdgaard D, Worning L, Sørensen JC, Pedersen PU. Testing a
reality orientation program in patients with traumatic brain injury in a
neurointensive care unit. J Neurosci Nurs. 2015 Feb;47(1):E2-10. doi:
10.1097/JNN.0000000000000106. PubMed PMID: 25565599.


10: Meier K, Nikolajsen L, Sørensen JC, Jensen TS. Effect of spinal cord
stimulation on sensory characteristics: a randomized, blinded crossover study.
Clin J Pain. 2015 May;31(5):384-92. doi: 10.1097/AJP.0000000000000131. PubMed
PMID: 25119512.
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