Neuroscience in Denmark


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General information

Name (center, department, group or other)
Department of Neurobioloby Research (Lambertsen lab)
Contact name
Kate Lykke Lambertsen
Contact email
klambertsen#at#health#dot#sdu#dot#dk
Contact title
Associate professor
Date
27. December 2016


Brief description of research activities

In our laboratory we are studying cerebrovascular diseases of and trauma to the central nervous system, such as stroke and spinal cord injury (SCI) to try to understand the cellular and molecular mechanisms that contribute to secondary neuronal cell death. We have primarily one main research objective, which is to study the neuro-inflammatory response that occurs following stroke and SCI with the aim to contribute to the development of novel therapies for stroke and SCI patients.

Keywords

Neuroinflammation, stroke, spinal cord injury, cytokines, TNF, microglia, functional outcome, neuroprotection

Research tools and techniques

Experimental animal models, multi plex analysis, flow cytometry, behavior, immunohistochemistry

Scientific Personnel

No of Associate Professors/Postdocs: 2
No of PhD students: 2
Other: 10

Key references from within the last 5 years

1. Clausen BH, Degn M, Sivasaravanaparan M, Fogtmann T, Andersen MG, Trojanowsky M, Gao H, Hvidsten S, Baun C, Deierborg T, Finsen B, Kristensen BW, Bak S, Meyer M, Lee J, Nedospasov SE, Brambilla R, Lambertsen KL (2016) Conditional deletion of myeloid increases neuronal sensitivity to focal cerebral ischemia. Sci Rep, 6, 29291; doi: 10.1038/srep29291.
2. Madsen PM, Clausen BH, Degn M, Thyssen S, Svensson M, Ditzel N, Finsen B, Deierborg T, Brambilla R, Lambertsen KL (2016) Genetic ablation of soluble TNF is associated with neuroprotection after focal cerebral ischemia. J Cereb Blood Flow Metab 36(9): 1553-1569.
3. Martin NA, Bonner H, Elkjær ML, D’Orsi B, Chen G, König HG, Svensson M, Deierborg T, Pfeiffer S, Prehn J, Lambertsen KL (2016) Deficiency of BID is partially neuroprotective in oxygen-glucose deprived organotypic hippocampal slice cultures, but not in a transient experimental stroke model. Front Cell Neurosci, Feb 3;10:14. doi: 10.3389/fncel.2016.00014.
4. Lambertsen KL, Østergaard K, Clausen BH, Hansen S, Stenvang J, Thorsen SB, Meldgaard M, Kristensen BW, Hansen PB, Sørensen GL, Finsen B (2014) Ablation of surfactant protein D in ischemic brain damage in mice. J Neuroinflam 11:123.
5. Novrup HG, Bracchi-Ricard V, Ellman DG, Ricard J, Jain A, Runko E, Lyck L, Yli-Karjanmaa M, Szymkowski DE, Pierce DD, Lambertsen KL*, Bethea JR* (2014) Central versus peripheral administration of XPro1595 is therapeutic following moderate spinal cord injury. (*Co-corresponding og delt seniorforfatterskab) J Neuroinflam 11:159.
6. Clausen BH, Degn M, Martin NA, Couch Y, Karimi L, Ormhøj M, Schmidt M-LB, Gredal HB, Gardiner C, Sargent IIL, Szymkowski DE, Petit G, Deierborg T, Finsen B, Anthony DC, Lambertsen KL (2014) Peripherally administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia. J Neuroinflam 11:203.
7. Bach A, Clausen BH, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K (2012) High-affinity, dimeric inhibitors of PSD-95 efficiently protect against ischemic brain damage. Proc Natl Acad Sci USA 109:3317-3322.
8. Lambertsen KL, Biber K, Finsen B (2012) Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab 32:1677-1698.
9. Lambertsen KL*, Gramsbergen JB*, Sivasaravanaparan M, Ditzel N, Sevelsted-Møller LM, Oliván-Viguera A, Rabjerg M, Wulff H, Köhler R (2012) Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels. PLoSOne 7:e47744. Epub 2012 Oct 15.


Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
info@thebrainprize.org
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund