Neuroscience in Denmark

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General information

Name (center, department, group or other)
Lipid group, Department of Drug Design and Pharmacology
Contact name
Harald S. Hansen
Contact email
Contact title
1. March 2017

Brief description of research activities

Mass spectrometry imaging of the lipidome during brain ischemia.
We are studying markers for neuronal death (formation of N-acyl-phosphatidylethanolamine) and for phagocytosis (accumulation of bis(monoacylglycero)phosphate, which is located in late endosomes and lysosomes), as well as signaling lipids like lysophosphatidylserine, sphingosine-1-phosphate, resolvins, ceramide, ceramide-phosphate, N-acylethanolamines, endocannabinoids, N-acyl-taurines etc, in relation to inflammation and resolution of inflammation


lipids, N-acyl-phosphatidylethanolamine, bis(monoacylglycero)phosphate, palmitoylethanolamide, resolvins, endocannabinoids, lysophosphatidylserine, N-acyl-taurine, lysophosphatidylcholine, inflammation

Research tools and techniques

mass spectrometry imaging (collaboration with associate professor Christian Janfelt, Department of Pharmacy)

Scientific Personnel

No of Associate Professors/Postdocs: 0
No of PhD students: 0
Other: 2

Key references from within the last 5 years

Nielsen MMB, Lambertsen K, Clausen, BH, Bhandari D, Meyer M, Larsen ST, Poulsen SS, Spengler B, Janfelt C and Hansen HS. (2016) Mass spectrometry imaging of biomarker lipids for phagocytosis and signaling during focal brain ischemia. Scientific Reports 6; 39571.
Okutan S, Hansen HS, Janfelt C. (2016) A simplified approach to cryo-sectioning of whole mice for imaging of drugs and metabolites with Desorption Electrospray Ionizarion Mass Spectrometry Imaging. Proteomics, 16; 1633-1641.
Wellner N, Janfelt C, Diep TA, Hansen HS (2013) Acylation of ethanolamine phospholipids and its biological functions in mammals. Biochim Biophys Acta Mol. Cell Biol. Lipids. 1831; 652-662.
Janfelt C, Wellner N, Hansen HS, Hansen SH (2013) Displaced Dual-Mode Imaging with Desorption Electrospray Ionization for simultaneous mass spectrometry imaging in both polarities and with several scan modes. J Mass Spectrometry. 48; 361-366.
Janfelt C, Wellner C, Leger PL, Kokesch-Himmelreich J, Hansen SH, Charriaut-Marlangue C, Hansen HS (2012) Visualization by mass spectrometry of two-dimensional changes in rat brain lipids, including N-acylphosphatidylethanolamines, during brain ischemia. FASEB J 26; 2667-2673.
Scherfigsvej 7
2100 Copenhagen Ø
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund