Neuroscience in Denmark


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General information

Name (center, department, group or other)
Kohlmeier Lab in the Department of Drug Design and Pharmacology, UCPH
Contact name
Kristi Anne Kohlmeier
Contact email
kak1#at#sund#dot#ku#dot#dk
Contact title
Associate Professor
Date
3. May 2017


Brief description of research activities

Our laboratory is interested in elucidating the neurobiology underlying arousal with the goal of identification of neural targets for managing or restoring appropriate and adaptive levels of arousal associated with human behaviours such as hyperarousal (insomnia), drug seeking behavior and hypoarousal (excessive daytime sleepiness, narcolepsy).

Main Projects:
Heteromeric interactions of CRH and Orx receptors mediating stress – induced arousal
Parkinson Disease-induced alterations of glutamateric signaling in REM- Sleep circuits
Glutamatergic plasticity induced in addiction-related circuitry by prenatal nicotine exposure
Stress hormone effects on ventral tegmental neurons critical in reinforcement circuitry

Keywords

Brain stem, in vitro, voltage clamp, electrophysiology, REM sleep, mouse, cholinergic, addiction

Research tools and techniques

Whole cell voltage clamp electrophysiology
Immunohistochemistry

Scientific Personnel

No of Associate Professors/Postdocs: 1
No of PhD students: 4
Other: 7

Key references from within the last 5 years

Lambert MØ, Ipsen T and Kohlmeier KA (2017) Acute Cocaine Exposure elicits rises in calcium in Arousal Related Laterodorsal
Tegmental Neurons, an effect altered by prenatal nicotine exposure. Pharm Res & Perspect. 5 (1):1-23.

Arvaniti M, Jensen MM, Soni N, Wang H, Klein AB, Thiriet N, Pinborg LH, Muldoon PP, Wieneck J M, Damaj I, Kohlmeier KA, Gondré-Lewis MC, Mikkelsen JC, Thomsen MS (2016) Functional interaction between Lypd6 and nicotinic acetylcholine receptors. J Neurochem. 138(6):806-20. doi: 10.1111/jnc.13718

Veleanu M, Axen TE, Kristensen MP and Kohlmeier KA (2016) Comparision of bNOS and ChAT in LDT and PPT: an immunohistochemical study. J Neuroscience Methods, 263:23-35.
Skøtt, MS, Andreasen, JT, Arvaniti, M and Kohlmeier, KA (2016) Nicotinic acetylcholine receptors in the pathophysiology of Alzheimer’s disease: The role of protein-protein interactions in current and future treatment. Current Pharmaceutical Design, 22(14):2015-34.

Soni N and Kohlmeier KA (2016) Endocannabinoid CB1R mediated rises in calcium and depolarization-induced suppression of inhibition within the Laterodorsal Tegmentum. Brain Struct Funct. 221(3):1255-77. doi: 10.1007/s00429-014-0969-4.

Christensen MH and Kohlmeier KA (2016) Age related changes in functional postsynaptic nAChR subunits in neurons of the laterodorsal tegmental nucleus. Addict Biol. 21(2):267-81. doi: 10.1111/adb.12194
Kohlmeier, KA (2015) Nicotine during Pregnancy-Changes induced in neurotransmission which could heighten proclivity to addict and induce maladaptive control of attention. J Dev Orig Health Dis. 6(3):169-81. doi: 10.1017/S2040174414000531

Hauberg K and Kohlmeier KA (2015) Ghrelin induces calcium rises in mouse laterodorsal tegmental neurons independently of a K- mediated depolarization-implications for a brainstem role in appetitive behaviors. Peptides. 2015 65:34-45. doi: 10.1016/j.peptides.2015.01.006.

dos Santos A, Barrato, G and Kohlmeier KA (2014) Treatment of Sleeping Disorders Should Be Considered in Clinical Management of Parkinson’s Disease. Opinion Article, Frontiers Aging Neurosci, Published: 09 October, doi: 10.3389/fnagi.2014.00273
Scherfigsvej 7
2100 Copenhagen Ø
Denmark
Tel. +45 39 12 80 00
CVR-nr. 11 81 49 13
info@thebrainprize.org
www.thebrainprize.org
Nils Axelsen Ralf Hemmingsen Lauritz Holm-Nielsen Ralf Hemmingsen Jens Oddershede Jens Frederik Rehfeld Anders Bjørklund