Neuroscience in Denmark


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General information

Name (center, department, group or other)
International Diabetic Neuropathy Consortium at Aarhus University
Contact name
Troels Staehelin Jensen
Contact email
tsjensen#at#clin#dot#au#dot#dk
Contact title
Director, Professor
Date
1. March 2018


Brief description of research activities

I was previous head of the Danish Pain Research Center at Aarhus University, which for 25 years have carried out pain research at Aarhus University and Aarhus University Hospital. This position is now taken over by my successor Prof Nanna B. Finnerup. I am now in addition to being professor at the Department of Neurology, Aarhus University Director of the International Diabetic Neuropathy Consortium based at Aarhus University which connects 4 universities. Aarhus University, South Danish University, University of Michigan, US and Oxford University, UK to basically understand the pathophysiology of diabetic neuropathy and the pain sometimes associated with it. The program which runs for 6 years and with 3½ years more to go examines the vascular disturbances in experimental diabetic neuropathy, metabolomic and lipidomic changes in experimental and clinical diabetic neuropathy, Epidemiological aspects based on two lareg cohorts: the ADDITION cohort and the DD2 cohort. Various techniques simple as well as more soffisticated are used to characterize the clinical profile of diabetic neuropathy

Keywords

Diabetic neuropathy, Pain; Clinical phenotypes; Metabolomics; Lipidomics; Morphological changes; Vascular changes

Research tools and techniques

clinical profiling; epidemiological techniques; Various Biochemical techniques; Two-Photon Microscopy, Optical coherence tomography, Experiemental models for neuropathy

Scientific Personnel

No of Associate Professors/Postdocs: 5
No of PhD students: 10
Other: 4

Key references from within the last 5 years

1. Sindrup SH, Holbeck J, Demant D, Finnerup NB, Bach FW, Jensen TS. Impact of etiology and duration of pain on pharmacological treatment effects in painful polyneuropathy. Eur J Pain 2017; 33: 1047-1052.
2. Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tölle T, Vollert J, Treede RD; German Neuropathic Pain Research Network (DFNS), and the EUROPAIN and NEUROPAIN consortia. Peripheral Neuropathic Pain: A mechanism-related organizing principle based on sensory profiles. Pain 2017; 158: 261-272.
3. Gonçalves NP, Vægter CB, Andersen H, Østergaard L, Calcutt NA, Jensen TS. Schwann cell interactions with axons and microvessels in diabetic neuropathy. Nat Rev Neurol 2017; 13: 135-147.
4. Demant DT, Lund K, Vollert J, Maier C, Segerdahl M, Finnerup NB, Jensen TS, Sindrup SH. The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: a randomised, double-blind, placebo-controlled phenotype-stratified study. Pain 2014; 155: 2263-2273.
5. Klit H, Hansen AP, Marcussen NS, Finnerup NB, Jensen TS. Early evoked pain or dysesthesia is a predictor of central poststroke pain. Pain 2014; 155: 2699-2706.
6. Jensen TS, Finnerup NB. Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms. Lancet Neurol 2014; 13: 924-935.
7. Karlsson P, Nyengaard JR, Polydefkis M, Jensen TS. Structural and functional assessment of skin nerve fibres in small-fibre pathology. Eur J Pain 2015; 19: 1059-1070.
8. Ostergaard L, Finnerup NB, Terkelsen AJ, Olesen RA, Drasbek KR, Knudsen L, Jespersen SN, Frystyk J, Charles M, Thomsen RW, Christiansen JS, Beck-Nielsen H, Jensen TS, Andersen H. The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy. Diabetologica 2015; 58: 666-677.
9. Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017; 16: 934-944.
10. Feldman EL, Nave KA, Jensen TS, Bennett DL. New horizons in diabetic neuropathy: Mechanisms, bioenergetics, and pain. Neuron 2017; 93: 1296-1313.


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