Danish Pain Research Center
Neuroscience in Denmark
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General informationName (center, department, group or other)
Danish Pain Research Center
Nanna Brix Finnerup
7. March 2018
Brief description of research activitiesNeuropathic pain research at the Danish Pain Research Center focuses on clinical studies in neuropathic pain. The aim is to increase our understanding of the underlying mechanisms and to improve treatment. A multidisciplinary research team uses quantitative sensory testing, neurophysiology, imaging, nerve blocks and other tests to study neuropathic pain mechanisms in pain models and patients with neuropathic pain. Epidemiological and prospective studies are used to assess the prevalence and risk factors. Clinical trials focus on biomarker-driven stratified trials, which test putative mechanism-based treatments. The examinations include symptom and sensory profiling as well as neurophysiological profiling and morphological findings of dermal and epidermal nerve fibers. Current areas include spinal cord injury pain, diabetic- and chemotherapy-induced painful polyneuropathy, postsurgical neuropathic pain, thermal sensory integration, neurophysiological assessment of pain mechanisms, neuropharmacology, clinical trials, and systematic reviews. Current major projects: EU Innovative Medicines Initiative 2: BioPain, the International Diabetic Neuropathy Center and the European Union Horizon 2020 DOLORisk Consortium (dolorisk.eu).
KeywordsNeuropathic pain, sensory nervous system, pain physiology, thermal sensory integration, polyneuropathy, postsurgical pain, spinal cord injury, cerebral palsy, stroke, pharmacology, neurophysiology
Research tools and techniquesQuantitative sensory testing, Randomized controlled trials, Imaging, Neurophysiology
Scientific PersonnelNo of Associate Professors/Postdocs: 3
No of PhD students: 3
Key references from within the last 5 years1. Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN. Neuropathic pain. Nat Rev Dis Primers. 2017;16;3:17002
2. Fardo F, Vinding MC, Allen M, Jensen TS, Finnerup NB. Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation. J Neurophysiol 2017;33:1047-52.
3. Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpää M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14:162-73.
4. Andresen SR, Bing J, Hansen RM, Biering-Sørensen F, Johannesen IL, Hagen EM, Rice ASC, Nielsen JF, Bach FW Finnerup NB. Ultramicronized palmitoylethanolamide in spinal cord injury neuropathic pain: a randomized, double-blind, placebo-controlled trial. Pain 2016;157:2097-103
5. Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB. Chemotherapy-induced pain and neuropathy: A prospective study in patients treated with adjuvant oxaliplatin and docetaxel. Pain 2016;157:560-8
6. Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice ASC, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic pain: An updated grading system for research and clinical practice. Pain 2016, 157:1599-606.
7. Schaldemose EL, Horjales-Araujo E, Svensson P, Finnerup NB. Altered thermal grill response and paradoxical heat sensations after topical capsaicin application. Pain 2015;156:1101-11
8. Schaldemose EL, Horjales-Araujo E, Demontis D, Børglum AD, Svensson P, Finnerup NB. No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals. Mol Pain 2014;10:76
9. Lund K, Vase L, Petersen GL, Jensen TS, Finnerup NB. RCTs May Underestimate Drug Effects: Balanced Placebo Trial Design. Plos One 2014;9:e84104
10.Cruccu G, Finnerup NB, Jensen TS, Scholz J, Sindou M, Svensson P, Treede RD, Zakrzewska JM, Nurmikko T. Trigeminal neuralgia: new classification and diagnostic grading for practice and research. Neurology 2016;87:220-8