Neuroscience in Denmark


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General information

Name (center, department, group or other)
Romero-Ramos Lab, Dept. Biomedicine, Aarhus University
Contact name
Marina Romero-Ramos
Contact email
mrr#at#biomed#dot#au#dot#dk
Contact title
Associate Prof.
Date
15. November 2018
(Last edited: 15. November 2018)

Brief description of research activities

The group started its research path on 2006, since then, they have focused their research on the neurodegenerative process in Parkinsonís disease and other alpha-synucleinopathies.
The team has during the last years studied and characterized those pathological events initiated as a consequence of the overexpression and or mishandling of the protein alpha-synuclein that contribute to the disease process. In addition, they have an interest on the processes occurring in the immune system during the neurodegenerative event and how both, local and peripheral immune cells, can modify the neuronal survival. Their fundamental goal is to reveal new targets for disease modification that can be ultimately used to develop novel therapies for the patients.
The lab's main tools of work are animal models of the disease: from neurotoxin based models to transgenic models, both classic transgenic mouse lines and adult transgenesis models by means of viral vectors. We are also using the fibril alpha-synuclein spreading model.

Keywords

Alpha-synuclein
Early vs. late Parkinsonís disease
Neurodegeneration
Microglia
Neuroinflammation
Neuroprotection
Monocytes
Immunomodulation
Immune-related Biomarkers


Research tools and techniques

Stereotactic Brain Surgery
Motor-behavioral analyses of rodents
Immuno-histological and anatomical analysis of brains
Sterological quantification of brain cells
Cytometric analysis of cells

Scientific Personnel

No of Associate Professors/Postdocs: 1
No of PhD students: 3
Other: 2

Key references from within the last 5 years

1. Ferreira SA, Romero-Ramos M. Microglia Response During Parkinson's Disease: Alpha-Synuclein Intervention. Front Cell Neurosci. 2018 Aug 6;12:24. Invited review.
2. Phan JA, Stokholm K, Jakobsen S, Vang K, Gjedde A, Landau AM, Romero-Ramos M. Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease. Sci Rep. 2017 Jul 25;7(1):6363
3. Tentillier N, Etzerodt A, Olesen MN, Filiz Rizalar S, Jacobsen J, Bender D, Moestrup SK and Romero-Ramos M, Anti-inflammatory modulation of microglia via CD163-targeted glucocorticoids protects dopaminergic neurons in the 6-OHDA Parkinsonís disease model. J. Neurosci. 2016, 36:9375-90.
4. Christiansen, JR; Olesen MN, Otzen D, Romero-Ramos M and Sanchez-Guajardo, V. α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology. J. Neuroinflam. 2016, 13:74.
5. Sanchez-Guajardo V, Annibali A, Jensen PH and Romero-Ramos M. α-Synuclein vaccination prevents the accumulation of pathological inclusions in striatum via Treg recruitment. J. Neuropathol. Exp. Neurol. 2013 247C:45-58.
6. Febbraro F., Just Andersen K., Sanchez-Guajardo V. and Romero-Ramos M. Chronic deferoxamine modulates pathology, immune response and motor defects in the α -synuclein rAAV Parkinsonís model. Exp. Neurol. 2013 72(7): 624-45.
7. Febbaro F., Sahin G., Diaz-Farranz A, Soares S, Jensen PH, Kirik D and Romero-Ramos M. Lack of Ser 129 phosphorylation of a-synuclein delays dopaminergic dysfunction and promotes abnormal accumulation in vivo, Neurobiol Dis. 2013 56:47-58.
8. Barkholt P., Sanchez-Guajardo V., Kirik D. and Romero-Ramos M. Long-term polarization of microglia upon α -Synuclein overexpression in non-human primates. Neurosci. 2012, 208:85-96.
9. Decressac M., Ulusoy A., Mattsson B., Georgievska B. Romero-Ramos M., Kirik D., BjŲrklund A. GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinsonís disease. Brain 2011, 134:2302-11
10. Sanchez-Guajardo V, Febbraro F, Kirik D and Romero-Ramos M. ďMicroglia acquire distinct activation profiles depending on the degree of α-synuclein neuropathology in a rAAV based model of Parkinsonís diseaseĒ PlosONE. 2010 Jan 20; 5(1): e8784


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Denmark
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thebrainprize@lundbeckfonden.com
www.thebrainprize.org
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